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Paradoxically, liver-specific FASN knockout promoted hepatic steatosis in mice on a zero-fat diet [60], in which steatosis developed alongside defective PPAR signaling and with a phenotype that could be corrected by dietary fat or a PPAR agonist [60]

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Obesity-induced suppression of sirtuin activity contributes to oxidative stress, impaired mitochondrial integrity, and potentially transgenerational metabolic dysfunction [54]